Cellular Senescence
Cellular Senescence is a biological process in which cells permanently lose their ability to divide, known as cell cycle arrest. This condition may occur as a result of cellular damage, stress, or cellular aging.
Although senescent cells remain alive, they may accumulate in tissues and exhibit altered biological functions. These cells can secrete a group of biomolecules known as the Senescence-Associated Secretory Phenotype (SASP), which includes cytokines, inflammatory mediators, and enzymes that affect tissue structure.
The accumulation of SASP factors may contribute to:
- Chronic inflammation
- Tissue degeneration
- Accelerated aging
- Increased risk of chronic diseases
Our laboratory provides testing for β-galactosidase activity using a staining method, which serves as an important biomarker of Cellular Senescence. This test can be performed on:
- Blood samples
- Cultured cells
It allows effective evaluation of cellular aging and senescence status.